Junctional Epidermolysis Bullosa 1 (JEB1) P735

59,90 €

Background

JEB is characterised by blister formation within the lamina lucida of the basement membrane zone. Clinical signs involve skin malformation resulting in blisters. Different areas of the body are affected, particularly the limbs. Affected foals die soon after birth.

Test specific information

At the moment two JEB-tests are available in different breeds. JEB is being caused by different mutations in the DNA for different horse breeds. Each mutation should be ordered separately.The first DNA test (JEB1) is suitable for draft horses. The second DNA test (JEB2) is suitable for American Saddlebred.

Age

The genetic factor is continuously present, and will always be visible.

Throughput

Normally the result can be expected within 15 working days. This turn-around-time starts when both the sample and the fully filled-out and signed submission form have been received.

Location of disease or trait

This disease mainly affects the skin.

Breed dependence

This DNA test is available for the following breeds: Draft Horses .

Sample type

For this DNA test we accept the following materials: Blood EDTA, Blood Heparin, Semen, Tissue, Hair. Please contact PharmaDNA if you wish to submit other material as listed.

Result

An animal can be free and has in that situation two healthy alleles. When used in breeding this animal will not become ill due to the disease. It cannot spread the disease in the population.An animal can be carrier and has in that situation one healthy and one disease allele. When used in breeding 50 percent of the offspring will receive the disease allele. Carriers will not become ill.An animal can be affected and has in that situation two disease alleles. When used in breeding all offspring will also receive the disease allele. Affected will become ill.

Inheritance

This genetic factor is inherited in an autosomal, recessive, mode. This means, that the individual can be free of the disease (homozygote normal), affected (homozygous affected) or carrier (heterozygous). Carriers may spread the mutation in a population without showing symptoms themselves. Because of this, it is extremely important to identify carriers correctly to prevent spreading of a mutation.

Severity of Disease

-

Darbo valandos

Mūsų pagalbos linija
veikia 8 valandas per parą

Pirm. - Penkt.: 9:00 - 17:00
Savaitgalis: Nedirbame

Pagalba gyvai

map
Vilnius: +370 5 2752600
Kaunas: +370 37 788503 
infodnr