Background
As in humans, also in dogs obesity is associated with a variety of health problems and reduced lifespan. A considerable and increasing number of dogs is obese. However, susceptibility to obesity varies between dog breeds due to the genetic
Background
. Labrador retrievers have the greatest documented obesity prevalence. A genetic study performed with animals of this breed and the closely related flat-coat retrievers identified a mutation, which is associated with increased body weight, adiposity and food motivation in these breeds.
Test specific information
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Age
Symptoms will develop at a young age. Within a few hours to a maximum of several weeks after birth, the characteristics that go with these genetic effects will become visible.
Throughput
Normally the result can be expected within 15 working days. This turn-around-time starts when both the sample and the fully filled-out and signed submission form have been received.
Location of disease or trait
This disease is present in the entire body, but causes main effects in the internal organs such as stomach, intestinal tract, liver and / or kidneys. In a number of cases, the disease affects one major internal organ.
Breed dependence
This DNA test is available for the following breeds: Labrador Retriever, Flat-Coated Retriever.
Sample type
For this DNA test we accept the following materials: Blood EDTA, Blood Heparin, Semen, Swab, Tissue. Please contact PharmaDNA if you wish to submit other material as listed.
Result
The disease is of multifactorial origin, which means that the symptoms are a result of the combination of genetic factors as well as the environment.For each genetic factor of a multifactorial disease, a favourable allele exists. The results for this allele are inidcated as 'Normal'. Animals carrying one copy of the undesirable genetic variant are indicated as 'Carrier', whereas animals carrying two copies of the undesirable genetic variant are indicated as 'Affected'.
Inheritance
The disease is of multifactorial origin, which means that the symptoms are a combination of genetic factors as well as the environment.
Severity of Disease
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